A 31-year-old member asked:
how come patients with diabetes mellitus type 2 are insulin resistant?
2 doctor answers • 3 doctors weighed in
Hospital-based practice 46 years experience
Insulin resistance: In patients with type 2 dm , Insulin resistance is one of the factors in addition to decreasing Insulin production. There are what are called Insulin receptors in the cells that Insulin attaches itself for its action. These receptors are down regulated or less in number. Sometimes, increasing the dose of Insulin may not work always because of this reason.
5670 viewsReviewed >2 years ago
Preventive Medicine 41 years experience
Partially Understood: Type ii dm typically develops slowly over decades without symptoms. Insulin resistance 1st, pancreas ↑es insulin+amylin output, up to 5x’s healthy. Sugar/carb intake ↑es Insulin output & drives storage as fat; fat cells binds Insulin more than muscle, thus vicious cycle. Low muscle mass & use ↓es muscle use of glucose, so more storage into fat. Fat secretes resistin which inhibits Insulin action.
5210 viewsAnswered Jan 28, 2019
Last updated Aug 10, 2019
Connect with a U.S. board-certified doctor by text or video anytime, anywhere.
$15 per month
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.