Is it okay to drink alcohol with naproxen?

In Moderate Amounts: Social drinking with Naproxen is typically fine. Things to be concerned about include GI upset with some drinks in conjunction with Naproxen especially if you are vomiting after heavy drinking further damaging the esophagus or GI system with acidic vomited contents. Naproxen in high doses can also erode the lining of the upper GI system.