Safe: Safe is such a relative term. Whenever taking multiple meds you run the risk of interactions or side effects. With that being said, realize that Effexor (venlafaxine) affects norepinephrine and seretonin, both of which are neurotransmitters associated with dep and anx; whereas, zoloft targets mainly seretonin. If prescribed both, attention needs to be paid to developing seretonin syndrome, which is an overload.
Answered 5/15/2016
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