A 42-year-old member asked:
Are there differences between zoloft and effexor (venlafaxine)?
2 doctor answers • 4 doctors weighed in
Family Medicine 40 years experience
Yes: Zoloft is a selective serotonin reuptake inhibitor. Effexor (venlafaxine) is a serotonin and norepinephrine reuptake inhibitor. Your doctor may choose either one based on your symptoms of depression and which might help you the most.
6.4k viewsAnswered >2 years ago
Psychiatry 54 years experience
Yes: Zoloft is serotonergic in nature. Effexor (venlafaxine) in low doses is also. At higher doses effexor's noradrenergic. Zoloft has fewer significant side effects - Effexor (venlafaxine) has more including at times severe withdrawal effects compared to zoloft. Studies show Effexor (venlafaxine) to be more effective in severe depression than other antidepressants. With its dual nature Effexor (venlafaxine) doesn't seem to lose effectiveness like zoloft.
6.4k viewsReviewed >2 years ago
A 39-year-old member asked:
What is the difference between Effexor (venlafaxine) and zoloft?
2 doctor answers • 6 doctors weighed in
Psychiatry 14 years experience
4.9k viewsReviewed >2 years ago
Last updated Sep 27, 2019
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