A member asked:

Are there differences between zoloft and effexor (venlafaxine)?

4 doctors weighed in across 2 answers
Dr. Matt Pflieger answered

Specializes in Family Medicine

Yes: Zoloft is a selective serotonin reuptake inhibitor. Effexor (venlafaxine) is a serotonin and norepinephrine reuptake inhibitor. Your doctor may choose either one based on your symptoms of depression and which might help you the most.

Answered 9/27/2019

6.4k views

Thank
Dr. Donald Hazlett answered

Specializes in Psychiatry

Yes: Zoloft is serotonergic in nature. Effexor (venlafaxine) in low doses is also. At higher doses effexor's noradrenergic. Zoloft has fewer significant side effects - Effexor (venlafaxine) has more including at times severe withdrawal effects compared to zoloft. Studies show Effexor (venlafaxine) to be more effective in severe depression than other antidepressants. With its dual nature Effexor (venlafaxine) doesn't seem to lose effectiveness like zoloft.

Answered 9/27/2019

6.4k views

Thank

Related Questions