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A 42-year-old member asked:

Are there differences between zoloft and effexor (venlafaxine)?

2 doctor answers4 doctors weighed in
Dr. Matt Pflieger
Family Medicine 40 years experience
Yes: Zoloft is a selective serotonin reuptake inhibitor. Effexor (venlafaxine) is a serotonin and norepinephrine reuptake inhibitor. Your doctor may choose either one based on your symptoms of depression and which might help you the most.
Dr. Donald Hazlett
Psychiatry 54 years experience
Yes: Zoloft is serotonergic in nature. Effexor (venlafaxine) in low doses is also. At higher doses effexor's noradrenergic. Zoloft has fewer significant side effects - Effexor (venlafaxine) has more including at times severe withdrawal effects compared to zoloft. Studies show Effexor (venlafaxine) to be more effective in severe depression than other antidepressants. With its dual nature Effexor (venlafaxine) doesn't seem to lose effectiveness like zoloft.

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Similar questions

A 39-year-old member asked:

What is the difference between Effexor (venlafaxine) and zoloft?

2 doctor answers6 doctors weighed in
Dr. James Fox
Psychiatry 14 years experience
SNRI vs SSRI: Effexor (venlafaxine) increases two different neurotransmitters in the brain (serotonin and norepinephrine) whereas zoloft increases just serotonin. Side effect profiles are similar. Withdrawal symptoms are worse with effexor (venlafaxine). People who don't respond to one, may respond to the other.

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Last updated Sep 27, 2019

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