What can i do about big toe pain when pressure is applied to the ball?

Sesamoiditis?: See a podiatrist. X-rays will determine if there is a sesamoid bone fracture or abnormality in these two bones under the great toe joint.

Meds and rest: Pain on the bottom of the great toe joint may be an inflamed two piece sesamoid bone or a fracture of the pea size bone. If rest, immobilization, and regular nsaids do not improve the condition within 2-4 weeks then you must seek a dr.