Can advair cause you to loose your voice?

Possibly: The Advair Diskus (salmeterol and fluticasone) is occasionally associated with laryngitis, especially if you are not rinsing your mouth after each use. Advair also comes in an hfa (inhaler), that should be used with a spacer/adapter to decrease these types of side effects.

Yes: I've seen this a number of times. It is the steroid component that does it. It usually goes away with stopping the medication, although not always.