No: Both zyrtec and Benadryl (diphenhydramine) belong to the same class of medicines called antihistamines. Taking both at the same time would be taking a double dose of medicine. Zyrtec is taken once every 12 hours, whereas Benadryl (diphenhydramine) is taken every 4 to 6 hours.
Answered 1/22/2015
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Sedation risk: Both zyrtec and Benadryl (diphenhydramine) are sedating antihistamines. They should not be taken together unless under the direction of your physician. Occasionally both will be prescribed for a severe case of hives or a severe allergic reaction but they are not usually taken together. The combination could result in over sedation, dizziness, incoordination, dry mucous membranes as well as more serious reactions.
Answered 5/10/2015
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