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Huntington Beach, CA
A 35-year-old male asked:

is it safe to take benadryl (diphenhydramine) and zyrtec within 12 hours of each other? zyrtec in the morning, and benadryl (diphenhydramine) before bed time?

2 doctor answers4 doctors weighed in
Dr. John Chiu
Dr. John Chiu answered
Allergy and Immunology 57 years experience
Yes: This a good combination especially if you have trouble falling asleep at night.
Dr. Lonna Larsh
Family Medicine 30 years experience
Yes: This is safe.

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Similar questions

A 32-year-old member asked:

Should i take Benadryl (diphenhydramine) until my zyrtec really kicks in?

1 doctor answer3 doctors weighed in
Dr. Brant Ward
Allergy and Immunology 13 years experience
Probably not helpful: Both drugs need to be absorbed by the GI system before they take effect to stop itching and sneezing (can take up to 1 hr). Benadryl (diphenhydramine) can dry up mucus (and make you sleepy), which zyrtec will not do at any time. If you have taken zyrtec for several days without relief from itching or sneezing, you may have something besides allergies (e.g. A cold) or need a different treatment. See your doctor.
Laurel, MS
A 36-year-old female asked:

I took a zyrtec about 12 hrs ago and was wondering if it was ok to take one benadryl (diphenhydramine)?

2 doctor answers4 doctors weighed in
Dr. Dan Fisher
Internal Medicine 27 years experience
Yes.: There should not be any significant interaction although both meds are in the same class.

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Last updated Nov 18, 2020
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