A member asked:

What is the chemical difference between duloxetine and fluoxetine?

A doctor has provided 1 answer
Dr. William Holmes answered

Specializes in Child Psychiatry

Differences: These two medicines share similarities, but they have different chemical structures, leading to different actions on the nervous system. Fluoxetine almost exclusively acts on the neurotransmitter serotonin, while duloxetine has a mixed action on both serotonin and norepinephrine. This difference will sometimes result in a person doing better with one medicine versus the other.

Answered 5/3/2014

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