Can fluctuating serotonin levels cause headaches?

Yes.: Serotonin is a critical neuro-signaling chemical; a deficiency may result in chronic pains, sleep disturbances, anxiety, depression and a propensity to overeat. Low serotonin levels are found in migraineurs and disorders they suffer with increased frequency including depression, irritable bowel syndrome, as well as, other chronic pain syndromes. The activity of serotonin can be altered with ssris, .