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Springfield, MO
A 26-year-old male asked:

Can periactin (cyproheptadine hydrochloride) (cyproheptadine) be useful in relieving serotonin induced migraine caused by an ssri? periactin (cyproheptadine hydrochloride) has antiserotonin affinity. head hurts..

1 doctor answer5 doctors weighed in
Dr. Bennett Machanic
Neurology 52 years experience
Might be useful: Although Cyproheptadine is nominally an anti-histamine, it does have seratonin antagonistic effects, and, has been best used as a migraine preventative in years past. Since it is cheap, could try it, but likely should start low dose and aim for about 4mg every 6 hrs. May take about two weeks to decide success at the higher dose.

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Last updated Apr 25, 2016

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