A 33-year-old male asked:
can periactin (cyproheptadine hydrochloride) (cyproheptadine) be useful in relieving serotonin induced migraine caused by an ssri? periactin (cyproheptadine hydrochloride) has antiserotonin affinity. head hurts..
1 doctor answer
Dr. Bennett Machanic answered
51 years experience Neurology
Might be useful: Although Cyproheptadine is nominally an anti-histamine, it does have seratonin antagonistic effects, and, has been best used as a migraine preventative in years past. Since it is cheap, could try it, but likely should start low dose and aim for about 4mg every 6 hrs. May take about two weeks to decide success at the higher dose.
Answered on Apr 25, 2016
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