What is the action of vincristine and doxorubicin and why can they be fatal to a cell?

Both drugs: Are . 40 years of use. Vincristine, a vinca alkaloid, inhibits the mitotic spindle needed to draw chromosomes apart during cell division. Cancer cells divide more often. Adria intercalates between dna strands preveneting replication and trtanscription: reading dna to make new stuff.

Both drugs block....: Cell cycle progression. Vincristine is a vinca alkaloid originally purified from periwinkle. It binds tubulin and prevents microtubule elongation. It blocks the mitotic spindle and causes mitotic arrest in dividing cells. Doxorubicin is an anthracycline. It is both an intercalating agent and an inhibitor of topoisomerase ii. It also promotes o2 free radical formation. Causes s-phase arrest.