Pill effect: An MI is a ratio obtained through performing a random count of three major cell types (parabasal cells, intermediate cells and superficial cells) that are shed from the squamous epithelium. The cell count is expressed as a percentage that reads as follows: MI= % parabasal cells, % intermediate cells, % superficial cells. Parabasal cells are the least mature cells having not been affected by estrogen or progesterone. Intermediate cells display mild maturation, having been affected by progesterone, and superficial cells display the most maturity, having been affected by estrogen. A patient’s MI can vary on a daily basis, and of course MIs vary from patient to patient. There are only two absolutes when it comes to cellular patterns in an MI: the first is that a predominance of parabasal cells indicates an absence of estrogen stimulation, and second is that a predominance of superficial cells indicates estrogen stimulation. Intermediate cells have little clinical usefulness. The maturation index is useful for the evaluation of therapies designed to treat vaginal hormonal symptoms.
Answered 8/21/2017
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