A member asked:

Any other diseases that o bands show up in csf not blood , besides ms?

4 doctors weighed in across 2 answers
Dr. Roy Arnold answered

Specializes in Internal Medicine

Yes: Examples of other diseases that can cause oligoclonal bands in the CSF include infections (eg, nervous system Lyme disease), autoimmune diseases, brain tumors, and lymphoproliferative diseases. Given how many diseases can result in oligoclonal bands in the CSF, the diagnostic utility of this finding is limited. Thanks for trusting HealthTap!

Answered 2/19/2015

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For sure: The oligoclonal band merely reflects spinal fluid immune globulin synthesis, and can be present with many immune or infectious disorders such as subacute sclerosing pan encephalitis, Lyme disease, neurosarcoidosis, neurosyphilis, and HIV, and although may be found in up to 97% of all MS patients, is still a nonspecific marker.

Answered 2/19/2015

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