How much pacreatic lipase is necessary to digest with a meal containing a 12 ounce steak?

Why do you ask?: Lipase taken orally is a fraudulent "cure-all" and if you are healthy, you'll make as much as you need as the food gets delivered. Only in severe pancreatic disease do we see people unable to digest ordinary food like you describe. And you won't find a particular quantity that's required -- enzymes work on substrates until the job is done.