I'm adpkd stage 3 renal failure, severe neuropathy (neck-down) daily cymbalta (duloxetine) 60mg & last 10days amitryptiline 50mg. feel agitated, paranoid. thanks.

Med interactions : The effects you feel likely derive from a combination of cymbalta, amitriptyline, azotemia, and nerve tracking. I have seen several CKD 3, 4, 5 patients have similar troubles with these meds. Dilaudid likely also contributes to nerve signal surges and recessions. Listed above is Dilaudid HP, (hydromorphone hydrochloride) which is high potency injectable. It interacts with amitriptyline in an adverse way. I recommend asap e

See provider: Please consider seeing your health care provider to check for worsening kidney function or other metabloic abnormalities are present and to see if adjusting your medicine is appropriate.