Why are cu and ceruloplasmin levels paradoxically low in wilson's disease?

Hepatic storage: The hepatocytes in wilson's disease (hereditary in the ainu) store copper, removing it from the circulation.

Minor mystery: Copper is low because ceruloplasmin is low; most copper in the blood is carried on the protein. Nobody really knows why ceruloplasmin tends to be low in Wilson's, and I hope that you also know that in about 30% of Wilson's patients it is not low at all, making is a very poor screening test.