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A 40-year-old member asked:

Why are cu and ceruloplasmin levels paradoxically low in wilson's disease?

2 doctor answers3 doctors weighed in
Dr. Martin Raff
Infectious Disease 56 years experience
Hepatic storage: The hepatocytes in wilson's disease (hereditary in the ainu) store copper, removing it from the circulation.
Dr. Ed Friedlander
Pathology 44 years experience
Minor mystery: Copper is low because ceruloplasmin is low; most copper in the blood is carried on the protein. Nobody really knows why ceruloplasmin tends to be low in Wilson's, and I hope that you also know that in about 30% of Wilson's patients it is not low at all, making is a very poor screening test.

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A 31-year-old member asked:

For what reason serum cu and ceruloplasmin levels are paradoxically low in wilson's disease?

1 doctor answer1 doctor weighed in
Dr. Ed Friedlander
Pathology 44 years experience
Not paradoxical: The problem is that copper can't get out of certain cells. The reason for ceruloplasmin being low is under study; since it carries copper, this metal also tends to be low. Checking serum copper and serum ceruloplasmin as a screen for wilson's misses up to a quarter of cases, especially if the person is already sick with anything.

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A 47-year-old member asked:
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Last updated Aug 9, 2014

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