My dentist has recommended the biopsy of the premalignant lesion. what should i do?

Have the biopsy: A premalignant lesion is called that because lesions of that type have a high risk of degenerating into cancer. Once the 'premalignancy' becomes actual cancer it is a much bigger problem to fix. Often times the biopsy removes all the abnormal cells. This will decrease the risk of degeneration into cancer to zero. Waiting to see what happens risk losing lots of normal tissue to cure a cancer.

Do biopsy: Biopsy is relatively easy procedure, with minimal discomfort afterwards. Your dentist will probably referr you to an oral surgeon or oral medicine specialist. Little piece of mucose tissue will be taken and send to pathology lab. You should get results in few days.

Do it!: In a situation like this, the lesion is suspected to be pre-malignant. There is no way to know if it has become malignant without doing the biopsy. The tissue is removed and submitted to a pathologist for analysis to check to see that the cancer has not broken through the basement membrane of the tissue and spread. Nothing good can come from waiting/postponing treatment.