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A 37-year-old female asked:

Is there a relation between polyclonal spike n increased plasma cells in the bone marrow pls answer?

2 doctor answers2 doctors weighed in
Dr. Haluk Tezcan
Medical Oncology 36 years experience
Short answer is yes: Reactive, meaning not malignant, causes of plama cell increase in bone marrow is not uncommon. In the setting of reactive processes such as inflammation, infection, cirrhosis, immune mediated anemias one can see an associated polyclonal increase in globulins (although I would not call that a spike).
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Dr. Mohammad Khan
Pediatrics 31 years experience
Relevance?: is there any relevance to any illness? Whenever there is polyclonal spike in the activity of the bone marrow, all cell types may increase in number. Plasma cells are related with B lymphocytes with more complex origination and maturation pattern involving lymphoreticular system.
Created for people with ongoing healthcare needs but benefits everyone.

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Last updated Sep 29, 2016

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