Immunohistology: Normal plasma cells in your bone marrow would not cause a high M spike. Rarely, abnormal plasma cells do not cause an M-spike. Causes of reactive bone marrow plasmacytosis include infection, malignancy, inflammation, Castleman’s disease, anemia, diabetes mellitus, cirrhosis. In most cases the plasma cell infiltrate is less than 20%, The cytoplasmic light chain ratio differentiates MUGUS
Answered 9/29/2016
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