Can i take metaxalone with nucynta (tapentadol) er?

Drowsiness: if taken together may have additive effect and can make you dizzy and drowsy and there is a risk of depressing your breathing which is a big risk for death

Be carefull: You can, but both are sedating. Take these at a time you do not need to drive or doing thins that need attention. Especially when you first start them Everyone is different and you may find you tolerate them find, but careful with first doses.

Yes but...: It is ok to do, but be careful regarding excessive sedation.