From excessive doses: In general, vitamin b6 is extremely safe and well-tolerated, though it may cause stomach upset in some (esp. If taken without food.However, taking high doses of b6 daily for months (usually at least 1000 mg but in some as low as 200 mg) can cause toxicity symptoms, most commonly peripheral neuropathy (tingling & numbness) also headaches, fatigue & irritability, which will dissipate upon stopping b6.
Answered 3/3/2015
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