Is it safe to take arthrotec (diclofenac and misoprostol) and 650mg acetaminophen at the same time or does it need to be spaced out a certain amount of time? thanks!

You can but...: Arthrotec (diclofenac and misoprostol) is a non-steroidal anti-inflammatory medication. It doesn't interact with acetaminophen, but I think you might get better pain control if you spaced them out. If you take your Arthrotec (diclofenac and misoprostol) three times a day wait four hours after your dose then take the acetaminophen. Give it a try and see if you have better pain control.

Yes: You can take acetaminophen with arthrotec (diclofenac and misoprostol). Be sure you do not take more than 4000 mg acetaminophen in a day. Good luck!