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A female asked:

Is there any type of drug test out there that can determine if someone took adderall vs. vyvanse (lisdexamfetamine)? or will they all just tell you amphetamine?

3 doctor answers12 doctors weighed in
Dr. Lynne Weixel
Clinical Psychology 37 years experience
Not from what I hear: Perhaps someone knows otherwise - but I've never heard that they can discriminate between amphetamines. Good luck.
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Dr. Robert Fietsam
Surgery - Thoracic 36 years experience
The formula of the two are very similar C9H13N and C9H12N, with one more hydrogen in Vyanse. Adderall actually has 4 isomers in it. There are complex chemical methods to identify them, but way beyond standard drug testing. So...no. Can't be differentiated.
Jul 19, 2014
Dr. William Singer
Pediatric Neurology 52 years experience
No: Adderall is a mixture of 4 different forms of amphetamine. Vyvanse (lisdexamfetamine) is just dexedrine sullfate. It will not be possible to distinguish them.
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Dr. Alan Wartenberg
A Verified Doctor commented
A US doctor answered Learn more
actually, Vyvanse is lisdexamfetamine, which is a pro-drug which has to be activated by stomach acid to be absorbed, which reduces the risk of people abusing it by snorting. It is metabolized to d-amphetamine. If very fancy testing is done (gas chromatography/mass spectroscopy or equivalent), the ratio of metabolites can sometimes give an idea of what was taken, but it's an educated guess.
May 22, 2015
Dr. Diane Minich
Family Medicine 38 years experience
No: cannot distinguish the two.
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Last updated Nov 2, 2021

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