Can we build resistance if we take too much insulin?

Insulin resistance: High insulin levels can promote insulin resistance. But it is important to control the blood glucose, and you have to do so somehow. Best way to break cycle is with diet/weight loss, so you need less insulin and insulin resistance will decrease. This is esp true with T2DM; with T1DM there are issues of how much short/long insulin and timing, but weight gain still an issue.