A member asked:

Just went from 20 mg of cymbalta (duloxetine) to 40 mg. how long until a therapeutic level would be noticed?

A doctor has provided 1 answer
Dr. Axel Martinez-Irizarry answered

Specializes in Family Medicine

About 6 Weeks.: Although the claim is made that some people may be able to start to feel less depressed within 2 weeks of taking one of these kinds of antidepressants, most people won’t start experiencing the full positive effects of the medication until 6 to 8 weeks after beginning it. It alters brain chemistry so it takes longer to get to those effects.

Answered 6/24/2014

3.9k views

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