A 47-year-old member asked:
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heterozygous for a1298c mutation on mthfr gene. can you explain this to me?

1 doctor answer
Dr. Ed Friedlander
43 years experience Pathology
Dubious lab test: There are several different alleles at the MTHFR locus and most (not all) of us in the pathology community are skeptical about the value of determining them, even in this era of defensive cover-your-butt medicine. The majority of people who are tested are told they have a "bad mutation" and one lab then offers dubious "nutritional supplements." Talk to a real geneticist.
Answered on Feb 2, 2017
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Dr. Ed Friedlander
43 years experience Pathology
Provided original answer
Thanks for the additional information. I would not be concerned in any case. Best wishes.
Jan 18, 2015

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Depends: The MTHFR 1298 mutation is not uncommon, but for any given individual to have the possibility of having it, one or both of their parents must have it.
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