Zoloft (sertraline) is giving me restless leg syndrome, will it continue to do so or will it stop over time.

Side effect: If this side effect has persisted for several days to two weeks unfortunately it will likely persist when antidepressants cause side effects consideration can be given to lowering the dose, changing medication, or adding a medicine to overcome the side effect.

See below: Most selective serotonin reuptake inhibitors like zoloft (sertraline) can worsen or even initiate restless legs syndrome in some people. Have it evaluated by a sleep doctor, to check for other causes such as a low ferritin level. But to answer your question, in some people it goes away and in some the RLS continues as long as zoloft (sertraline) is there. Discuss other options w/ your prescribing dr. Also, avoid caffeine.