Symptoms fatigue / headaches/ malaise. work up 2008 negative except elevated crp now elevated crp 2.73, sed rate 22, ana positive speck 1:40, ch50>60?

That's good: I would urge you to draw no conclusion from any sed rate reading that's not extremely high unless there's specific symptoms and signs. Millions of healthy young adults have positive ANA at a titer of 1:40 speckled. I'd urge you to get into a fitness-focused lifestyle, hang out with quality friends and do meaningful things. Best wishes.