Mt Plymouth, FL
A 32-year-old female asked:
Why can hydroxyzine be used for anxiety but not diphenhydramine? both are antihistamines, one derived from the other, correct?
1 doctor answer • 1 doctor weighed in

Dr. Margret Rose Dellossoanswered
Clinical Psychology 21 years experience
Not same effects: In same class of drugs as Diphenhydramine but has antagonistic effects on several receptor sites in the brain which means it works to treat anxiety, mild depression and unhealthy thought processes.
Created for people with ongoing healthcare needs but benefits everyone.
4.2k viewsAnswered >2 years ago
Last updated Jul 14, 2018
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