Is prp more effective than prolotherapy?

PRP vs. Prolotherapy: Prp is used when dextrose prolotherapy stops being effective or levels out. Platelets contain powerful growth factors which increase healing and angiogenesis. Dextrose prolotherapy, stimulates musculoskeletal healing but also provides growth factors to the tissue not all prp is the same. Different types appropriate for different problems. More studies are needed.

Platelet Rich Plasma: There is not much good data that I am aware of showing that prolotherapy is effective. PRP or platelet rich plasma is showing effectiveness in small studies for several indications. These include: Facial rejuvenation, hair regrowth, sexual rejuvenation, arthritis and musculoskeletal injuries, and more. Based on my experience, I recommend PRP therapy.

I do both--PRP wins: Short answer: I have done both in my practice and I now do almost exclusively PRP. Long answer: Prolotherapy is specifically designed to stimulate the inflammatory response--I have had patients with significant soreness after the injection because of this. PRP works in a similar pathway but there's better research on it, and I have seen it tolerated better in my patients.