Should your levothyroxine dose also go down when your weight goes down ?

Tests: Not really. You medication dose is based upon you thyroid test results, not your weight.

Significant: Reductions in weight may reduce your need for replacement slightly, but minor changes in weight will not. Also, your body can accommodate for many of these changes. Finally, you need to make sure you're taking brand name T4 replacement for consistency and accuracy. Check w/ your doctor.