Alcohol and smoking on hrt, is it okay to do this?

No, esp smoking: With alcohol, depends on dose. Safe drinking in women amounts to no more than one standard drink per day, and never more than 4 on one occasion. Smoking greatly increases the chance of blood clots on hormone replacement therapy, which is one of the main side effects of estrogen. This is true whether it is oral contraceptives or hormone replacement therapy. You increase your chances of embolus.