Will alcohol and smoking affect my kidneys?

Yes: Tobacco causes vascular, blood vessel, disease all over body i.e. Heart, brain, legs, and kidneys, etc. Excess alcohol hurts the overall circulatory system and liver, both affect kidneys. You get heart & liver failure from heavy use. While moderation in alcohol does not have well documented risk it does not have any benefits for heart or others.How to define moderation? Better quit both.

Not directly: How much alcohol are we talking about? Normal social use (1-2 drinks per day at most in men, 1 per day in women and older people) has little or no effect. Alcohol abuse rarely effects the kidneys; smoking, by increasing arteriosclerosis, can effect the kidneys by reducing their blood supply.