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A 21-year-old member asked:

How can antidepressants relieve irritable bowel syndrome pain?

2 doctor answers • 4 doctors weighed in
Dr. Holly Barth
Dr. Holly Barthanswered
General Practice 11 years experience
Decrease Stress: Stress/anxiety makes the symptoms of IBS worse. The goal of giving antidepressants to a patient is to reduce their stress, thus decreasing the IBS symptoms. Antidepressants increase serotonin levels in nerve endings. The GI tract and the brain have receptors to which serotonin increasing medicines (antidepressants) bind. Increasing serotonin in the GI tract decreases IBS symptoms.
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6.2k viewsReviewed >2 years ago
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Dr. Vikas Duvvuri
Dr. Vikas Duvvuri agrees1 doctor agrees
Dr. Vikas Duvvuri
Dr. Vikas Duvvurianswered
Psychiatry 18 years experience
Gut has serotonin: Common antidepressants (ssris like prozac) act on serotonin and the gut has more serotonin than the brain.
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Dr. Pamela Pappas
Dr. Michael Sparacino
Dr. Pamela Pappas and another doctor agree2 doctors agree

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Last updated Oct 3, 2016

Found in:

Bowel›Pain›IBS (irritable bowel syndrome)

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