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Haslett, Michigan
A 45-year-old female asked:

Is 300mg of wellbutrin xl daily and 40 mg of cymbalta (duloxetine) daily safe to take together?

2 doctor answers4 doctors weighed in
Dr. Pamela Pappas
Psychiatry 44 years experience
Interaction: Although these 2 can be used together safely, caution is needed with the doses. Wellbutrin can inhibit the metabolism of cymbalta, (duloxetine) causing its level to rise in your system. Seizures are possible if doses are too high also. Please discuss your concerns with your prescribing psychiatrist.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Raju Indukuri
Psychiatry 47 years experience
Comb meds: Wellbutrin xl 300 mg and may be 30 mg Cymbalta (duloxetine) are safe. There is no 40 mg cymbalta (duloxetine). Even a 60 mg Cymbalta (duloxetine) is safe. But you should be monitored by a doctor.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Pamela Pappas
Psychiatry 44 years experience
Cymbalta comes also in a 20mg size -- 2 of those = 40mg.
Nov 23, 2013
Last updated Mar 16, 2021

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