I have hypothyroidism with pos tpo, low-t, adrenal insufficiency. have gotten worse on synthroid (thyroxine) and trt. does negative ana rule out schmidt syndrome?

Not useful: ANA / anti-nuclear antibody isn't a marker for schmidt's. In fact, with your history, the question's perhaps moot. It's critical that you monitor your adrenal function -- especially since if you should for some reason get your thyroid replacement adjusted upward, you cover your possible underlying coexisting adrenal insufficiency. Not to do so can be catastrophic. You need a good endocrinologist.