Was on many medications for confirmed ms (rebif, copaxone, gilenya, tysabri, (natalizumab) tecfidera) none helped control.. is this typical of ms? next step?

Challenging: This is quite unusual, and makes me wonder whether indeed you have MS or a condition which might mimic MS. Would suggest full reassessment including testing for neuromyelitis optica (aquaporin 4), evaluations for Lyme disease, CADASIL, vitamin B-12 and vitamin D deficiencies, perhaps syphilis and HIV, maybe anti-phospholipid antibody syndrome.