2-3 days: For most smokers. After a single exposure to tobacco smoke, cotinine can be detected in blood or urine for less than 24 hours, but in an individual smoking 1/2 pack or more per day, 2-3 days is common. It is rarely positive after 5 days. Hair testing can detect cotinine (main metabolite) for months, depending on length of hair. Nicotine is very short-acting and is only present for hours.
Answered 8/4/2017
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