Question 1

what is the difference between neurofibromatosis1 and neurofibromatosis 2?

Accepted Answer

Etiology: Nf 1 also called von recklinhausen, caused by single gene disorder on chromosome 17 and causes non cancerous lumps.
Nf 2 also called central neurofibromatosis caused by mutation of merlin in chromosome 22q12. 10% of all nf and causes bilateral acoustic tumors.

Question 2

is there any difference between neurofibromatosis 1 and neurofibromatosis 2?

Accepted Answer

Etiology: Neurofibromatosis (nf) 1 is called von recklinghouse, caused by single gene disorder on chromosome 17, causes non-cancerous lumps.
Nf 2 also called central nf is a mutation of merlin in chromosome 22q12, 10% of all nf and causes bilateral acoustic tumors.

Question 3

what is the infant mortality rate from neurofibromatosis 1?

Accepted Answer

Poor prognosis: Congenital generalized (disseminated) neurofibromatosis (detected prenatally) is associated with  poor prognosis, with  mortality rate of 92%.

Question 4

please help! what is the infant mortality rate of neurofibromatosis 1?

Accepted Answer

Depends  amt. of nf: Congenital generalized (disseminated) neurofibromatosis (detected prenatally) is associated with a poor prognosis, with a mortality rate of 92%. Survival rates for patients detected before and after birth were 28% and 62%.However most cases of nf are focal and not disseminated without evidence of increased infantile mortality rate. In people with nf the overall decrease in life span is about 8 yrs.

Question 5

would a diagnosis of neurofibromatosis 1 be a disqualifier for being a living kidney donor?

Accepted Answer

No: As you are not transmitting genetic disease as in sperm donor , if you are healthy and your own health is not at risk , kidney donation is permissible

Question 6

is it normal for optic nerve tumors to cause impairment in vision (neurofibromatosis 1)?

Accepted Answer

Possible: Neurofibromatosis type i can sometimes involve optic nerve gliomas (tumors of the main nerve for the eye), and this can definitely affect vision. Discuss your symptoms with your doctor.

Question 7

is there any difference between neurofibromatosis and elephant man's disese?

Accepted Answer

No same: Same, neurofibromatosis  nf1  von recklinghusen's disease) is disease genetically transmitted, when had disfiguring extensive skin manifestations involving face  also called elephant man's disease. Original famous ( and tragic ) patient is joseph merrick ( 862-1890 ).

Question 8

when do cafe au lait spots stop appearing that indicates neurofibromatosis? i have two on my buttocks that have been confirmed by dermatologist. should i worry? would i have more by now if i had neurofibromatosis? would i know by now if i had it?

Accepted Answer

Ignore them: It is normal for people to have  a few. You would need 8 or more sizable spots by your age to fall under suspicion for that disorder.

Question 9

my son has neurofibromatosis type 1 and he is only 2 years old. what symptoms can i expect?

Accepted Answer

NF 1 is caused by : mutations of the NF gene, 17q11.2. Clinical course varies widely  depending largely  on location &amp; size of brain, skin, eye &amp; other tumors. Initial evaluations by a geneticist, ped. neurologist, ped. ophthalmologist, developmental/behavioral pediatrician. &amp; Early Intervention, http://www.dds.ca.gov/EarlyStart/home.cfm., guide management. Learning Disabilities &amp; ADHD are common. See www.ctf.org.

Question 10

my sister has neurofibromatosis type 2. she only has the cafe spots on her body. will i develop it too? is there a chance she will get a tumor? :(

Accepted Answer

Neurofibromatosis: Are you certain your sister has NF2?  What about NF1?  The reason for asking is that cafe au lait spots are not used to diagnose NF2.  What about your parents?

Many cases are spontaneous, and you may never develop symptoms of NF.  It depends on which type we are talking about and what other family members have it.

Once you are sure of the diagnosis then your questions may be answered.

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Doctor answers about:

What is the difference between neurofibromatosis1 and neurofibromatosis 2

A member asked:

What is the difference between neurofibromatosis1 and neurofibromatosis 2?

A member asked:

Is there any difference between neurofibromatosis 1 and neurofibromatosis 2?

A member asked:

What is the infant mortality rate from neurofibromatosis 1?

A member asked:

Please help! what is the infant mortality rate of neurofibromatosis 1?

A member asked:

Would a diagnosis of neurofibromatosis 1 be a disqualifier for being a living kidney donor?

A member asked:

Is it normal for optic nerve tumors to cause impairment in vision (neurofibromatosis 1)?

A member asked:

Is there any difference between neurofibromatosis and elephant man's disese?

A member asked:

When do cafe au lait spots stop appearing that indicates neurofibromatosis? i have two on my buttocks that have been confirmed by dermatologist. should i worry? would i have more by now if i had neurofibromatosis? would i know by now if i had it?

A member asked:

My son has neurofibromatosis type 1 and he is only 2 years old. what symptoms can i expect?

A member asked:

My sister has neurofibromatosis type 2. she only has the cafe spots on her body. will i develop it too? is there a chance she will get a tumor? :(

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