Question 1

can blast cells be seen on normal cbc? if not, how are they found?

Accepted Answer

Terminology: If blast cells are present it is no longer a normal cbc. Blasts can be seen on smear of peripheral blood as well as smear of bone marrow. Flow cytometry is an other way to find blast cells.

Question 2

can blast cells show up on cbc? why sometimes manual review is necessary?

Accepted Answer

Yes: This is critical. Even one blast cell on peripheral smear is extremely serious. Some automated cell-counters using image analysis may mistake them for normal lymphocytes or monocytes. There's still no artificial-intelligence substitute for the human eye. If a hematologist suspects myelodysplastic syndrome, leukemia or some other myeloproliferative disease, they will look at the smear themselves.

Question 3

i read that you have millions of b cells. how does one b cell find the right specific antigen it fits to if there's so many of them?

Accepted Answer

Antigens get held...: Each B cell recognizes only 1 unique antigen. We need &gt; 1 million B cells to ensure most antigens are recognized. Collectively, B cells could likely recognize any organic molecule that could exist. The process does not rely on random encounters. Specialized cells trap and hold antigens where circulating B cells get the chance to recognize them.

Question 4

what is the difference between blast like cell and blast cell? got one blast-like cell in peripheral blood, what does that indicate?'a

Accepted Answer

No malignancy: The blast cell are leukemia cell and can confirm with antigen test, but blast like are not malignant and are negative by antigen test.

Question 5

if the immune system targeted specific nerves cells why would the body not be able to feel the process of those nerves cells being attacked?

Accepted Answer

No sensory nerves...: If there are no sensory nerve endings in that part of the body, then no sensations are detected, so thus the brain receives no information (and so we don't "feel" anything going on). Imagine a city with 1000 security cameras. There will be "blind spots" in places that the cameras aren't looking. The police do not see things that are happening in the "blind spots".

Question 6

what specific nerves/cells would be seriously damaged if you have complete loss of feelings emotions empathy inhibitions loss of electrical changes ?

Accepted Answer

None: Your feelings and emotions are a process of your central nervous system (your brain and the hormones/chemicals in your brain).  Discuss your disease and feelings with your physician.  You may be experiencing Depression, a treatable condition.  There is help available.

Question 7

what is the difference between plasma cells n blast cells?

Accepted Answer

Cell Type: Plasma cells are a specific type of white blood cell and can be normal or abnormal depending upon the context.  Blast cells are an immature cell found in the bone marrow whcih under normal circumstances lead to the production of cellular components of blood (WBC, plateltes, RBC).  In leukemias that is a break in the maturation process of these cells leading to an accumulation of "blast Cells".

Question 8

can you tell me how a stem cell become a specific cell type?

Accepted Answer

Stem cells: have 2 fates. They can self replicate to provide a primitive pool for life. They can differentiate, which means grow and produce offspring which develop into specific cell types

Question 9

is it typical to see 1% blasts and 2% myelocytes in white cell differential in high risk mds? are they the same thing?

Accepted Answer

More info needed.: Unless the blasts have been present before, this would be a concerning finding.  You should discuss this with your doctor and understand what is going on and what the trend in your counts has been..  Myelocytes are a less mature form of white cell and can be seen under a variety of conditions.

Question 10

mastocytosis has specific diagnostic criterion.   does mast cell activation syndrome have specific criterion?  if so, what is the criterion?

Accepted Answer

Mast cells: These are several diseases with ill defined criteria that do not constitute enough evidence to call them mastocytosis but may be a prerequisite for it.

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Doctor answers about:

What are the specific blast cells

A member asked:

Can blast cells be seen on normal cbc? if not, how are they found?

A member asked:

Can blast cells show up on cbc? why sometimes manual review is necessary?

A member asked:

I read that you have millions of b cells. how does one b cell find the right specific antigen it fits to if there's so many of them?

A member asked:

What is the difference between blast like cell and blast cell? got one blast-like cell in peripheral blood, what does that indicate?'a

A member asked:

If the immune system targeted specific nerves cells why would the body not be able to feel the process of those nerves cells being attacked?

A member asked:

What specific nerves/cells would be seriously damaged if you have complete loss of feelings emotions empathy inhibitions loss of electrical changes ?

A member asked:

What is the difference between plasma cells n blast cells?

A member asked:

Can you tell me how a stem cell become a specific cell type?

A member asked:

Is it typical to see 1% blasts and 2% myelocytes in white cell differential in high risk mds? are they the same thing?

A member asked:

Mastocytosis has specific diagnostic criterion. does mast cell activation syndrome have specific criterion? if so, what is the criterion?

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