Question 1

4%plasma cells in bone marrow biopsy-how serious is it?

Accepted Answer

Up to 5% is normal as long as they are not "monoclonal" meaning derived from a cell.  If monoclonal then a bone cancer called myeloma needs to be ruled out.  If no bone disease, anemia, high calcium or kidney disease answer is MGUS, a pre-cancerous condition with low risk of progression (less than 1% per year).

Question 2

Multiple myloma specialist needed pls help me confusing reports low m spike below 1 no crab but 14 percent plasma cells in bone marrow biopsy worried ?

Accepted Answer

Your plasma cells >10% in the bone marrow biopsy mean either smoldering myeloma or active myeloma. If you have elevated calcium, anemia, renal insufficiency or lytic bone lesions, I'm sorry to say you have myeloma. If not, you have smoldering myeloma. Go to this link for more info: http://www.nccn.org/patients/guidelines/myeloma/index.html

Question 3

Hi pls gve me insight in a bone marrow biopsy results which says 15 percent plasma cells?

Accepted Answer

Plasma cells are a normal component of bone marrow.  A higher percentage than normal can indicate certain conditions such as multiple myeloma or MGUS.  It is important to understand that any test needs to be interpreted in the context of other clinical findings.  Discuss these results with your physician to figure out the diagnosis.

Question 4

I had a bone marrow biopsy done a few days ago and the results just appeared on my health record. is this bad? abnormal plasma cells present (plasma cells show a mild lambda predominance, and aberrant coexpression of cd56?

Accepted Answer

Multiple myeloma or AL amyloidosis come to mind. Presence of anemia,high serum calcium,bone pain are characteristics of myeloma. Both plasma cell dyscrasias can cause kidney damage & have elevated serum lambda or kappa light chains. A hematologist oncologist is best to evaluate & advise you. A serum& urine immunofixation,24 hour urine total protein are often key. Congo red stain shows amyloid

Question 5

Final diagnosis my value 1-3 bone marrow (biopsy, clot, aspirate) -cellular marrow with trilineage hematopoiesis -plasma cells account for 5% of cellularity. any sign of cancer? and how to post entire biopsy results it only allows 250 spaces to type?

Accepted Answer

If you have monoclonal gammopathy and bone marrow biopsy was done for ruling out multiple myeloma, you likely do not have this condition (less than 5% chance) and you have a condition called MGUS (monoclonal gammopathy of undetermined significance). You should be monitored by an oncologist in the future. However, if there is light chain in your urine, you may need to be treated.

Question 6

Does the presence of bright cd8 t-cells on bone marrow biopsy indicate cancer?

Accepted Answer

Presence of cancer cells  is only  indication of cancer no other cells., to call it a cancer you have to see cancer cells  nothing else . Cd-8  t cells are seen in viral infections also . These cells are  some times   seen surrounding the tumor or inside the tumor which  is a good prognostic sign  presence of immunity , body is fighting the cancer.

Question 7

Bone marrow biopsy: focal areas show tiny aggregates of lymphoid cells (10-12) - reactive. is this alarming for an nhl patient?

Accepted Answer

Represent bm involvement by lymphoma.

Question 8

40yo/f.rec labs uploaded.chronic lymphocytosis.had bone marrow biopsy checking for cancer,only found small cluster of mast cells, show cd25 and spindled.but no ckit mutation and normal tryptase levels.blood stays about the same?been followed over 1yr?

Accepted Answer

All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, what you uploaded is not accessible to the doctors on this site.    
Wish you good health!

Question 9

Is a bone marrow biopsy painful?

Accepted Answer

Any biopsy will be painful but in the hands of an experienced doctor and proper sedation (local novocaine) it can be a much more tolerable process. Pain killers such as tylenol (acetaminophen) afterwards for 24-58 hours can be a help too.

Question 10

What amount is a bone marrow biopsy?

Accepted Answer

I am not clear what you are asking--do you want to know how much bone marrow is removed during a bone marrow biopsy?
Generally, 5-15 cc's of marrow is removed during a bone marrow aspiration and then a 2-3 cm small piece of the bone marrow is removed for the biopsy.

If you were trying to get other information please add a more detailed question.

Plasma cells in bone marrow biopsy

4%plasma cells in bone marrow biopsy-how serious is it?

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Multiple myloma specialist needed pls help me confusing reports low m spike below 1 no crab but 14 percent plasma cells in bone marrow biopsy worried ?

Hi pls gve me insight in a bone marrow biopsy results which says 15 percent plasma cells?

I had a bone marrow biopsy done a few days ago and the results just appeared on my health record. is this bad? abnormal plasma cells present (plasma cells show a mild lambda predominance, and aberrant coexpression of cd56?

Final diagnosis my value 1-3 bone marrow (biopsy, clot, aspirate) -cellular marrow with trilineage hematopoiesis -plasma cells account for 5% of cellularity. any sign of cancer? and how to post entire biopsy results it only allows 250 spaces to type?

Does the presence of bright cd8 t-cells on bone marrow biopsy indicate cancer?

Bone marrow biopsy: focal areas show tiny aggregates of lymphoid cells (10-12) - reactive. is this alarming for an nhl patient?

40yo/f.rec labs uploaded.chronic lymphocytosis.had bone marrow biopsy checking for cancer,only found small cluster of mast cells, show cd25 and spindled.but no ckit mutation and normal tryptase levels.blood stays about the same?been followed over 1yr?

Is a bone marrow biopsy painful?

What amount is a bone marrow biopsy?

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