Question 1

what does a high level of immunoglobulin m mean?

Accepted Answer

Several causes: Multiple myeloma, early infections, rheumatoid arthritis and some kinds of kidney disease can cause this. The likely causes can vary with the age of the person. You need to discuss this with your physician.

Question 2

what does it mean if i have high immunoglobulin m  qn serum?

Accepted Answer

Waldenstrom's Dz: An elevation of immunoglobulin m (igm) in the serum esp. If monoclonal (of one kind) raises the possibility of waldenstrom's macroglobulinemia - a malignancy affecting lymphocytes or plasma cells that produce this abnormal IgM protein causing symptoms of hyperviscosity - confusion, shortness of breath, stroke, kidney damage etc.

Question 3

what does it mean if your immunoglobulin m is low and your hemoglobin alc is high?

Accepted Answer

Unrelated: They are unrelated.  Low IgM is usually not clinically significant (depending on how low of course).  Talk to an allergist immunologist to figure this out.  A high A1c would suggest diabetes.  Talk to your primary care doctor.

Question 4

what does it mean if your immunoglobulin m is elevated?

Accepted Answer

Depends: If IgM is elevated but IgA & igg are decreased then you have a significant immunodeficiency called hyper IgM syndrome. Other causes of elevated IgM include monoclonal gammopathy and multiple myeloma. Never ignore the possibility of a lab error - the next test to do is to repeat the IgM level.

Question 5

what does it mean when your rdw and immunoglobulin m are high and your  anachoice screen is positive?

Accepted Answer

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the findings suggest auto-immune red cell loss. It would be prudent to see your doctor who ordered these tests.

Question 6

i have a very low igg3 and igg4, along with a very low immunoglobulin m and a high serum amyloid a - what does this mean?

Accepted Answer

See immunlogist: The low igg3 and igg4 in and of themselves may not mean much if your igg1 is normal.  The fact that you also have low igm suggests that there may be an immune disorder.  The high serum amyloid a likely signifies inflammation in your case. www.ncbi.nlm.nih.gov/.../10608507‎.

Question 7

is it normal to have borderline low immunoglobulin m (igm) levels?  do they fluctuate that much?...or nothing to worry about?  doc wasn't worried.

Accepted Answer

Don't worry: It may fluctuate but i won't be concerned with an isolated low igm, let alone a borderline low one.
The immunoglobulin levels , like any other products produced by the body, do fluctuate a little with time but usually within a narrow range in a healthy person. Some levels may elevate in the presence of infections or allergen exposure.

Question 8

can you explain what this might mean: "apparent polyclonal gammopathy: igm.  kappa and lambda increased".  immunoglobulin m is also high at 437.?

Accepted Answer

Monoclonal processes: Are often malignant or pre malignant.  Polyclonal processes are usually reactive/infectious/inflammatory.

Question 9

what would cause free kappa &free lamba to be high but ratio normal also immunoglobulin m, qn, serum high. platelets steady rising & wbc high for 1yr?

Accepted Answer

Hematologist: A hematologist is best qualified to answer your question. Your findings suggest monoclonal spike in the  electrophoresis and some sort of bone marrow proliferative disorder.

Question 10

been diagnosed with peripheral neuropathy   blood test showed high immunoglobulin m w/polyclonal gammopathy. kappa/lambda increase. possible meaning?

Accepted Answer

PlasmaCellDIsorder: May have plasma cell disorder/multiple myeloma.  Plasma cells are a type of white blood cells that produces immunoglobulin(antibodies).  Multiple myeloma is a cancerous or excessive proliferation of these plasma cells which may lead to excessive high levels of calcium/bone pain/renal failure/anemia (low blood counts).  Need to see hematologist (blood doctor specialist).

Get Virtual Care

For Businesses

About Us

HealthTap Online Primary Care Doctors Accepting New Patients

Doctor answers about:

High immunoglobulin m levels

A member asked:

What does a high level of immunoglobulin m mean?

A member asked:

What does it mean if i have high immunoglobulin m qn serum?

A member asked:

What does it mean if your immunoglobulin m is low and your hemoglobin alc is high?

A member asked:

What does it mean if your immunoglobulin m is elevated?

A member asked:

What does it mean when your rdw and immunoglobulin m are high and your anachoice screen is positive?

A member asked:

I have a very low igg3 and igg4, along with a very low immunoglobulin m and a high serum amyloid a - what does this mean?

A member asked:

Is it normal to have borderline low immunoglobulin m (igm) levels? do they fluctuate that much?...or nothing to worry about? doc wasn't worried.

A member asked:

Can you explain what this might mean: "apparent polyclonal gammopathy: igm. kappa and lambda increased". immunoglobulin m is also high at 437.?

A member asked:

What would cause free kappa &free lamba to be high but ratio normal also immunoglobulin m, qn, serum high. platelets steady rising & wbc high for 1yr?

A member asked:

Been diagnosed with peripheral neuropathy blood test showed high immunoglobulin m w/polyclonal gammopathy. kappa/lambda increase. possible meaning?

HealthTap Online Primary Care Doctors Accepting New Patients

Telemedicine

Primary Care

Manage Your Conditions

Women's Health

Children's Health

Men's Health

Senior Health

Wellness, Prevention & Lifestyle

Sexual Health

Mental & Behavioral Health

Travel Medicine

Urgent Care

Didn't find what you're looking for?

More of what we treat

Allergies

Antibiotics

Asthma

High Blood Pressure

Prescriptions

Type 2 Diabetes

For Businesses

Company

Health Content

Join Us

Download HealthTap

Questions?