Question 1

Help! dr tapered me off zyprexa (olanzapine) and adderall too quickly due to worse depression.? day 23 severe wd. took 5mg of adderall helped. dopamine depletion?

Accepted Answer

Dopamine depletion is a relic of the 1980's.  Much too simplistic an answer as synaptic neurotransmission is only one part of the story as we now know (i.e. CREP, epigenetics, non-synaptic neurotransmission, etc).  Taking Adderall and Zyprexa (olanzapine) together makes me wonder what you are being treated for and by whom.

Question 2

Is it possible or probable that the drug adderall, (dextroamphetamine and racemic amphetamine) if used long-term, could cause eventual dopamine depletion?

Accepted Answer

Amphetamines have been used therapeuticly for over 90 years.  There is no evidence of depletion of dopamine brain stores from the therapeutic use.

Question 3

Does longterm adderall usage lower serotonin? rather,when dopamine goes up does serotonin go down with longtime usage?

Accepted Answer

Adderall blocks the re-uptake of dopamine, which increases the amount between neurons. If you are a person with naturally low levels of dopamine, the adderall would bring the level up to normal. If normal or high levels of dopamine, the adderall would push you to abnormally high levels. That overstimulation is toxic to the brain. Not sure of the direct impact to just serotonin.

Question 4

Adderall(specifically dopamine) makes my ocd worse, but also makes me happy and takes away my social anxiety.why does it help and hurt me at same time?

Accepted Answer

Medications can have differing effect. Need to balance them out for optimal effect.

Question 5

I have been on adderall xr 30mg morning and 30mg instant release at night for 20 years and now have depleted my neurotransmitters and wanted to ask if you know the specific medications or medications types that will upregulate my dopamine receptors?

Accepted Answer

Let's get REAL: You have NOT "depleted my neurotransmitters" in spite of being medicated "for 20 years".  Seriously doubt that your Amphetamines have caused you to need to "upregulate my dopamine receptors".   Since you seem concerned, find a psychiatrist who is focused on the use of medications, get this evaluated, and then decide on future needs.  Or we here at HT could do a virtual consult.

Question 6

If exercise raises dopamine levels will the levels be to high if i also take adderall (dextroamphetamine and racemic amphetamine)?

Accepted Answer

Exercise  does not cause hormones and neurotransmitters to increase to a level that would be considered excessive. Regular exercise is a good thing for everyone and can help with the increased activity seen in adhd. It can also help with focus and attention. Physical activity has a positive impact on cognitive functioning so put on your running shoes and get going.

Question 7

Will i ever get my dopamine back after twelve years of adderall (dextroamphetamine and racemic amphetamine) use of 30 mg?

Accepted Answer

Your brain has plasticity to restore your neurotransmitter levels back to your initial levels after some time. It is possible that they were low to start with, and have been increased by the stimulant treatment. We have no methods to measure Dopamine levels in the brain, and Dopamine is not the only neurotransmitter involved. Don't worry if you need another type of treatment now.

Question 8

If i took too much adderall (dextroamphetamine and racemic amphetamine) a year ago, am left with complete loss of pleasure 24/7, what med will help dopamine to start flowing again?

Accepted Answer

It's possible Wellbutrin (bupropion) might help.

Question 9

Since my adderall (dextroamphetamine and racemic amphetamine) overdose 1 yr ago (been clean since), i can't feel any emotion or feelings of pleausure, none. could it have depleted my dopamine?

Accepted Answer

Brintellix has a fairly high incidence of sexual dysfunction.It acts on NE and serotonin transport and receptors Neurontin (gabapentin) can cause a major numbing effect as well. 
Seroquel can have a lot of side effects as well. (it has the greatest effect on dopamine receptor activity). That being said, I suggest that you make no change in your medication without the advise of your prescribing physician.

Question 10

Can weaning off zyprexa (olanzapine) and adderall & stopping at the same time cause major problems with dopamine levels and brain function. if so what? day 22 off

Accepted Answer

Adderall clears quickly and symptoms will likely rebound and require management. Zyprexa (olanzapine) clears slowly and requires slow taper to prevent withdrawal symptoms and need to observe for target symptom return. Follow the guidance of the prescriber for best experience and report any adverse effects or return of symptoms to the prescriber. Best regards.

Adderall dopamine depletion

Help! dr tapered me off zyprexa (olanzapine) and adderall too quickly due to worse depression.? day 23 severe wd. took 5mg of adderall helped. dopamine depletion?

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Is it possible or probable that the drug adderall, (dextroamphetamine and racemic amphetamine) if used long-term, could cause eventual dopamine depletion?

Does longterm adderall usage lower serotonin? rather,when dopamine goes up does serotonin go down with longtime usage?

Adderall(specifically dopamine) makes my ocd worse, but also makes me happy and takes away my social anxiety.why does it help and hurt me at same time?

I have been on adderall xr 30mg morning and 30mg instant release at night for 20 years and now have depleted my neurotransmitters and wanted to ask if you know the specific medications or medications types that will upregulate my dopamine receptors?

If exercise raises dopamine levels will the levels be to high if i also take adderall (dextroamphetamine and racemic amphetamine)?

Will i ever get my dopamine back after twelve years of adderall (dextroamphetamine and racemic amphetamine) use of 30 mg?

If i took too much adderall (dextroamphetamine and racemic amphetamine) a year ago, am left with complete loss of pleasure 24/7, what med will help dopamine to start flowing again?

Since my adderall (dextroamphetamine and racemic amphetamine) overdose 1 yr ago (been clean since), i can't feel any emotion or feelings of pleausure, none. could it have depleted my dopamine?

Can weaning off zyprexa (olanzapine) and adderall & stopping at the same time cause major problems with dopamine levels and brain function. if so what? day 22 off

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