What can decrease the serum levels of sex hormone binding globulin?

Exercise & fat loss. Sex hormone binding globulin (shbg) is related to estrogen levels which are related to body fat. So the non-drug way to get around this is via exercise & nutrition in order to get rid of excess body fat, esp around your gut. If you can't lower your estrogen levels enough, some physicians (myself included) will attempt an off-label trial of an aromatase inhibitor to stop your body's conversion of t.

Related Questions

What supplements can decrease the levels of sex hormone binding globulin?

Don't know of any. Shbg is affected by sex hormones. Estrogen increases and male hormones including testosterone decreases shbg. Lowering Insulin levels with a very low carbohydrate high fat diet will improve metabolic health that would ultimately increase shbg. Read more...