A member asked:

Can i take pseudoephedrine hci with lexapro (escitalopram)? and what about phenylephrine? the first one has been my preferred cold med for years.

29 doctors weighed in across 14 answers

Either one is fine.: Be aware that those chemicals can cause a false positive urine amphetamine on a urine toxicology test. Best wishes.

Answered 1/21/2017

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Dr. Patrick Tapia answered

Specializes in Psychiatry

It should be okay: You should be fine although there are very rare instances of people having excessive vasoconstriction throughout their brain with taking Pseudoephedrine and it was thought that this was related to excessive serotonin. There is also a proposed instance of serotonin syndrome after the combination of Pseudoephedrine and Paxil (paroxetine) in a person with peripheral artery disease. The risks are relatively low.

Answered 6/17/2017

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Likely no problem.: You likely will be able to tolerate pheylephrine with your lexapro (escitalopram). The most difficult time to combine would be if you were starting Lexapro (escitalopram) or increasing the dose. At those times, patients can have an increased arousal state, which if combined with an activating agent like phenylephrine could be not only uncomfortable but possibly dangerous. I still recommend you call your doctor to discuss this.

Answered 3/17/2019

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Dr. Alvin Lin answered

DrugDrugInteractions: Yes, you can take Pseudoephedrine w/lexapro (http://www.Drugs.Com/interactions-check.Php?Drug_list=1964-0, 1013-565). However, it's always best to tell your prescribing doctor & dispensing pharmacist everything you're taking, whether prescription or otc, so that they can pre-emptively look for drug-drug interactions before prescribing you something.

Answered 3/12/2020

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Dr. Oscar Novick answered

Specializes in Pediatrics

Lexapro (escitalopram): You can take Lexapro (escitalopram) and phenylepherine together without causing problems. If you take Lexapro (escitalopram) with Pseudoephedrine your concentration may suffer and you may be more irritable.

Answered 6/30/2014

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Medications: You can take either, but know that side effects of decongestants include agitation and may cause anxiety. If you have been able to tolerate Pseudoephedrine in the past without much side effects, you should be fine.

Answered 11/27/2017

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Dr. Anthony Vertino answered

Specializes in Clinical Psychology

Yes: Cold medicine should not interact with your lexapro (escitalopram). It is always advisable to consult with your physician as well.

Answered 5/14/2016

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Dr. Eric Levin answered

Specializes in Psychiatry

Should be ok: Your not on brand Lexapro (escitalopram) and generic? Also how often do you use cialis? If you begin to have heart palpitations or sleep disturbances, restlessness or headaches during the day, then check you pulse and blood pressure. Pseudoephedrine & phenylephrine, could effect cardiac, CNS etc. But infrequently. See package insert. Risk per100 people or per 1000 is usually small. See ent, meds or ballooning ?

Answered 1/8/2018

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See below YES: I found no drug interactions. However, everybody's different, so check with your physician.

Answered 1/21/2017

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Dr. Pamela Pappas answered

Specializes in Psychiatry

No interactions: There are no interactions between your Lexapro (escitalopram) and the cold medicines you list. However, in some people Pseudoephedrine and phenylephrine can cause or worsen anxiety.

Answered 1/21/2017

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Drug interaction: Either Pseudoephedrine or phenylephrine can be taken with Lexapro (escitalopram) without significant interactions.

Answered 9/4/2017

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Dr. Gebrehana Zebro (formerly Woldegiorgis) answered

Specializes in Internal Medicine

No significaqnt: Interaction between Lexapro (escitalopram) and Pseudoephedrine . Beware of rebound congestion if you use the medication for prolonged time . Do not forget also to be aware of your blood pressure elevation.

Answered 2/19/2019

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Dr. Bachar Al-Alami answered

Specializes in ADHD & Autism

Can't mix/Ask Doc: Data demonstrate that the specified agents may interact with each other in a clinically significant manner. The benefits of concomitant use of these two medications usually outweigh the risks. An appropriate monitoring plan should be implemented to identify potential negative effects. Dosage adjustments of one or both agents may be needed in a minority of patients.

Answered 3/5/2017

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Dr. Robert Grieco answered

Specializes in Family Medicine

Better to avoid: Decongestants like the ones mentioned work by acting somewhat like Adrenalin and can cause your heart to race, keep you up and feel anxious. These side effects can be exaggerated if taking Lexapro (escitalopram) especially if that is one of the problems you are taking it for. It would be safer to use a topical decongestant like afrin nasal spray as long as you keep it to 3 days or less.

Answered 9/19/2018

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