Can expired afrin (oxymetazoline) still be used?

Throw it away: I would not use any expired product with the exception of adrenaline or Epinephrine if it is a lifesaving situation and nothing else is available. Throw away expired meds.

Agree w Dr. Klein: Recommend that expired oxymetazoline not be used. After the episode that oxymetazoline has been used for passes – toss the container (to avoid contamination).