Can statin drugs increase creatinine level?

Yes: While very uncommon, all of the statin drugs have been known to cause muscle injury. The release from injured muscle of a substance called myoglobin can plug up the kidneys and cause the creatinine to rise. However, under those circumstances there is usually significant muscle pain or weakness and often the urine has a reddish appearance. Also a muscle enzyme (CPK) will be strikingly elevated.