Both antihistamines: Diphenhydramine (also known as benadryl) is an antihistamine that is typically used to treat allergic reactions. It is somewhat sedating and causes drowsiness. Dimenhydrinate (dramamine) is also a histamine that is typically used to treat motion sickness. The body metabolizes dimenhydrinate into diphenhydramine, but this takes some time and leads to a slower onset of effect.
Answered 9/16/2017
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Diphenhydramine: Diphenhydramine is an antiallergy drug best known as benadryl (diphenhydramine). Dimenhydrinate is an over-the-counter drug used to prevent nausea and motion sickness. Dimenhydrinate is a combination of two drugs: Diphenhydramine and 8-chlorotheophylline, a chlorinated derivative of theophylline.
Answered 4/18/2016
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