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A 37-year-old female asked:

What does having bone marrow cells move to and enlarge the liver and spleen indicate in myelofibrosis? does this change the prognosis?

2 doctor answers3 doctors weighed in
Dr. Hamidreza Sanatinia
Internal Medicine - Hematology & Oncology 28 years experience
Advanced stage: When bone marrow cells move to spleen/liver, it may mean bone marrow is failing & cannot make blood cells effectively. Therefore, the spleen & liver take over to do the job- then they get enlarged & blood count also drops & many patients may require transfusions. Patients may have fevers etc. Treatment is available for enlarged spleen & fevers. (jakafi).Younger patients may need transplant.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Mehdi Moezi
Medical Oncology 33 years experience
Yes: If you have mf and now getting splenomegaly it means disease is progressing. If you are the patient at age 37 you need to explore definitive treatment strategy ask for bone marrow transplant referral.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Sep 10, 2016

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